Following the recommendation of the recent PAT
initiative of the FDA, the concerned industries are
supposed to better the quality of the present
manufacturing methods by a sound science-based
understanding of all unit operations. Product quality is
supposed to be designed a priori as stipulated by the
FDA slogan ”Do it right the first time”. If quality is to be
build into the products, we can no longer rely on the
empirical know-how of the manufacturing artists, but
have to control all possible interactions of the process
parameters.
Today, having available sophisticated on-line control
instruments and process simulation computer tools,
we are technically better equipped than ever before.
This workshop is supposed to show innovative
approaches for building quality into products.
Who should attend
Researchers, formulators, production managers and
quality managers from the industries concerned.
| Program | ||
| Tuesday 26 September 2006 | ||
| 08.45 | LogIN | |
| 09.00 | Introduction | Hans Leuenberger |
| 09.15 | Correlating drug-binder adhesive strength measured using inverse gas chromatography with tablet performance | Frank Thielmann |
| 10.00 | Artificial neural networks as decision support systems in pharmaceutical product development | Aleksander Mendyk |
| 10.45 | Coffee break | |
| 11.15 | The truth about high shear granulation | Jonathan Seville |
| 12.00 | Lunch buffet | |
| 13.15 | Differences between batch and semi-continuous processing of high shear granulation and fluid bed drying | Kaspar van den Dries |
| 14.00 | On-line monitoring and optimization of a fluid bed granulation process | Jörg Worlitschek |
| 14.45 | On-line monitoring /control of high shear granulation | Constantijn Sanders |
| 15.30 | Coffee break | |
| 16.00 | Application of NIR spectroscopy for quantitative determination of both active ingredients and excipients in a solid dosage form | Adám Z. Dávid |
| 16.45 | Reflectance spectroscopy as a tool for in-process control of a coating process | István Antal |
| 17.30 | End of 1st day bus transfer to the hotel | |
| 19.30 | Wine tasting incl. dinner | |
| Wednesday 27 September 2006 | ||
| 09.00 | PAT control of fluidized bed processing with industrial applications for coating and drying | Ingela Niklasson-Björn |
| 09.45 | Microwave technology as a tool for monitoring solid dosage form processes | Jochen Dressler |
| 10.30 | Coffee break | |
| 11.00 | Quantification of microcapsule coating quality | Frédéric Depypere |
| 11.45 | Acoustic monitoring of the coating process | Kaisa Naelapää |
| 12.30 | Lunch buffet | |
| 13.45 | Modeling of air flow through the Wurster process chamber and validation of CFD results | Rok Dreu |
| 14.30 | PAT implementation example for on-line tablet analysis with FT-NIR-spectroscopy | Urban Fäh |
| 15.15 | Coffee break | |
| 15.45 | Process focused galenical tablet research and development | Jörg Petersen |
| 16.30 | Modeling a horizontal pan tablet coating process | Carl Wassgren |
| 17.15 | End of 2nd day bus transfer to the hotel | |
| 19.30 | Workshop banquet | |
| Thursday 28 September 2006 | ||
| 09:00 | Multi-level modeling of the fluid bed coating process | J.A.M. Kuipers |
| 09.45 | Population balance modeling as a tool for understanding fluidized bed coating | Stefan Heinrich |
| 10.30 | Coffee break | |
| 11.00 | Finite element models in powder technology | Maxim Puchkov |
| 11.45 | Snack Buffet and LogOUT | |